This evidence check focused on the barriers and enablers of implementing a patient centred medical home model of care. The evidence check found that the patient centred medical home model has the potential to improve quality of care, and enhance the experiences of primary care of patients and staff. However, it requires a major change effort for most practices, involving changes to work roles, processes, and implementation of new technology. There are many potential barriers that can impact the success of implementation. However, lessons have been reported in the literature, many of which can be implemented as strategies to overcome these challenges.